How to correctly Dose CBD

How to correctly Dose CBD

Not sure how to dose your CBD? Not feeling the benefits right away? Don’t worry! The fact is everyone’s bodies are different and will metabolise CBD to different extents.  Both the amount (dose) and medium of taking CBD, play a large role. Here are a few tips on how to make CBD the most effective for you.


CBD can be taken, usually using a tincture, sublingually by placing a few drops under the tongue and hold it there for 30 to 90 seconds before swallowing. The CBD is then directly absorbed into the blood stream. Using this method, smaller doses are usually necessary, and the benefits are felt faster than when taken orally because the CBD enters circulation directly. Some research has indicated this method makes CBD more easily and consistently available to the body. 2

CBD oils can also be mixed into food and drink for oral administration.


CBD can be applied on the skin topically, at targeted areas, for relief of pain/inflammation. The CBD gets absorbed into the skin and allows the effects of the CBD to be focused where needed most. This method also allows the affects to be felt almost instantaneously.

The CBD can also be applied via a transdermal gel/cream to the skin. In this case the CBD can penetrate into deeper tissues and gets absorbed into the bloodstream and can be effective for the whole body.


CBD and tablets are gaining popularity, for their ease of use and consistency in dosage.  When CBD is taken orally, before it reaches its site of action, it must first pass through the liver. In our liver we have metabolising  enzymes that will remove a portion of the CBD ingested. Each individual has different amounts of these enzymes in their liver and will thus end up with varying amounts of CBD in their bloodstream. It is also important to note that CBD has a low oral bioavailability and so higher doses are usually required when taken via this method.

One of the main barriers when trying CBD for the first time is optimizing dosage. While there are no dangers in taking larger amounts, more isn’t always better. Not only this, but it also depends on what you are taking the CBD to treat. It has been widely reported that CBD has what is known as a ‘bell-shaped dose response curve’ when treating a variety of conditions. 1 Now, let’s break that down to what it actually means:

  • ‘dose response curve’- a graph showing how the therapeutic effectiveness of the drug changes in response to dose
  • ‘bell shaped’ - as you increase the dose the affects increase until it hits a peak and then the therapeutic benefits decrease as you reach higher doses. See graph below

This creates an issue when advising people on how much to take. Most medications plateau once they reach their maximum effect at higher doses and of course depending on their toxic threshold (maximum amount taken before adverse effects are seen) have a fairly wide therapeutic range. This means it is possible to give a dosage to the public that accounts for the differences in each patient’s biochemistry. Whereas in the case of CBD, its therapeutic window is much narrower and so the dose required for each individual may vary a lot more.

What we here at thedrugstore recommend is to start at lower end of the recommended dose gradually increase every 2-3 weeks until you experience your desired result and if you find the effects falling try decreasing your dose.

CBD is quickly becoming a popular supplement for individuals looking for natural non-psychoactive relief. For those thinking of trying CBD, be patient it will just take time to find the best product and dosage that works for you.


1. A. W. Zuardi, N. P. Rodrigues, A. L. Silva, S. A. Bernardo, J. E. C. Hallak, F. S. Guimarães and J. A. S. Crippa, Front. Pharmacol., 2017, 8.

2. P. S. Fasinu, S. Phillips, M. A. ElSohly and L. A. Walker, Pharmacotherapy, 2016, 36, 781–796.

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